Schools participating in the 2001 Science Bowl:
| Abraham Lincoln, Council Bluffs |
Clear Creek Amana, Tiffin |
Humboldt | Pella |
| Ames | Clear Lake | Iowa City West | Regina, Iowa City |
| Ankeny | Clinton | Kennedy Cedar Rapids |
Saydel, Des Moines |
| Bellevue | Corwith-Wesley-LuVerne, Corwith | Keumper, Carroll | Sioux City East |
| Bishop Heelan, Sioux City |
Davenport Assumption | LeMars | South O’Brien, Paullina |
| Boone | Davenport West | Manson NW Webster, Manson | Tri-Center, Neola |
| Burlington | Davis County, Bloomfield |
Marshalltown | Urbandale |
| Cedar Falls | Dowling, West Des Moines | Mediapolis | Wahlert , Dubuque |
| Central Academy Des Moines |
East Union Afton |
Newton | Washington Cedar Rapids |
| Chariton | Fort Dodge | North Scott, Eldridge | Washington |
| Clarion-Goldfield, Clarion |
Gilbert | Northwood-Kensett, Northwood | Waverly-Shell Rock, Waverly |
| Clay Central/Everly, Everly |
Hempstead, Dubuque | Ogden | Winterset |