Chemical Analysis of Nanodomains
Personnel
Project Leader(s):
Emily Smith
Principal Investigators:
Ning Fang, Jacob Petrich, Emily Smith
Overview
We seek to understand the basic principles that underlie energy-relevant chemical separations; develop analytical methods to improve the sensitivity, reliability, and productivity of analytical determinations; and to develop new approaches to analysis. Our research emphasizes instrumentation and technique development highly relevant to the main focus areas of the Separation and Analysis activities of the Division of Chemical Science, Geoscience and Biosciences within the DOE Office of Basic Energy Sciences.
The goal of this research is to develop the next generation of imaging tools and methodologies for the analysis of phenomena that occur at nanometer length scales and picosecond time scales. The developed instrumentation and methodology will be applied to model systems of interest to the DOE mission, where fundamental insight can be gained with the high spatial and temporal resolution afforded by our developed methods: chemical reac tions in heterogeneous silica supported catalysts; the organization and dynamics of mixed model lipid bilayers and cell membranes; chromatographic interactions; and heterogeneous enzyme reactions. The methods we propose to develop are:
1. High resolution total internal reflection (TIR) Raman microspectroscopy and imaging
2. Sub-diffraction limited imaging, including differential interference contrast (DIC) microscopy, variable-angle evanescent-field (EFM) microscopy, and time-resolved stimulated emission depletion (STED) microscopy
3. Novel single molecule spectroscopies
This research is supported by the U.S. Department of Energy, Office of Basic Energy Sciences, Division of Chemical Sciences, Geosciences, and Biosciences through the Ames Laboratory. The Ames Laboratory is operated for the U.S. Department of Energy by Iowa State University under Contract No. DE-AC02-07CH11358.
Publications
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Nalwa K S; Carr J A; Mahadevapuram R C; Kodali H K; Bose S; Chen Y Q; Petrich J W; Ganapathysubramanian B; Chaudhary S . 2012. Enhanced charge separation in organic photovoltaic films doped with ferroelectric dipoles. Energy & Environmental Science. 5:7042-7049. abstract
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Mckee K J; Meyer M W; Smith E A . 2012. Near IR Scanning Angle Total Internal Reflection Raman Spectroscopy at Smooth Gold Films. Analytical Chemistry. 84:4300-4306. abstract
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Ma C B; Han R; Qi S D; Yeung E S . 2012. Selective transport of single protein molecules inside gold nanotubes. Journal of Chromatography A. 1238:11-14. abstract
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Gu Y; Di X W; Sun W; Wang G F; Fang N . 2012. Three-Dimensional Super-Localization and Tracking of Single Gold Nanoparticles in Cells. Analytical Chemistry. 84:4111-4117. abstract
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Xiao L H; Wei L; Liu C; He Y; Yeung E S . 2012. Unsynchronized Translational and Rotational Diffusion of Nanocargo on a Living Cell Membrane. Angewandte Chemie-International Edition. 51:4181-4184. abstract
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Marchuk K; Guo Y J; Sun W; Vela J; Fang N . 2012. High-Precision Tracking with Non-blinking Quantum Dots Resolves Nanoscale Vertical Displacement. Journal of the American Chemical Society. 134:6108-6111. abstract
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Wang G F; Fang N; Conn P M . 2012. Detecting and Tracking Nonfluorescent Nanoparticle Probes in Live Cells. Imaging and Spectroscopic Analysis of Living Cells: Optical and Spectroscopic Techniques. 504:83-108. abstract
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Ha J W; Sun W; Stender A S; Fang N . 2012. Dual-Wavelength Detection of Rotational Diffusion of Single Anisotropic Nanocarriers on Live Cell Membranes. Journal of Physical Chemistry C. 116:2766-2771. abstract
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Bose S; Barnes C A; Petrich J W . 2012. Enhanced stability and activity of cellulase in an ionic liquid and the effect of pretreatment on cellulose hydrolysis. Biotechnology and Bioengineering. 109:434-443. abstract
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